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ACROBiosystems Human Fas Ligand / TNFSF6 Protein, His Tag, active trimer

MALS verified

Marque:  ACROBiosystems FAL-H5241-1MG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15876707

  • 3127.26€ / 1mg
Date d’expédition estimée: 07-01-2022

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Description

Description

Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.8 kDa. The protein migrates as 25-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spécification

Spécification

AAH17502.1
HEK293
Human
18.8 kDa
1 mg
Pro 134 - Leu 281
FASLG,ALPS1B,APT1LG1,CD178,CD95L,FASL,TNFSF6
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>90% as determined by SDS-PAGE
Human Fas Ligand, His Tag, active trimer (FAL-H5241) is expressed from human 293 cells (HEK293). It contains AA Pro 134 - Leu 281 (Accession # AAH17502.1).
-20°C
Fas Ligand
His Tag
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