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ACROBiosystems Human IL-1 RII / CD121b Protein, Fc Tag

Marque:  ACROBiosystems IL2-H4256-100UG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15867037

  • 262.28€ / 100µg
Date d’expédition estimée: 29-12-2021

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Description

Description

Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 63.9 kDa. The protein migrates as 68-74 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spécification

Spécification

NP_004624.1
HEK293
Human
63.9 kDa
100 µg
Phe 14 - Glu 343
CD121b,IL1RB,IL1R2,CDw121b
Unconjugated
50 mM Tris, 100 mM Glycine, pH7.5
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Human IL-1 RII, Fc Tag (IL2-H4256) is expressed from human 293 cells (HEK293). It contains AA Phe 14 - Glu 343 (Accession # NP_004624.1).
-20°C
IL-1 RII
Fc Tag
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