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ACROBiosystems Human IL-2 R beta / CD122 Protein, Fc Tag
SPR verified
Marque: ACROBiosystems ILB-H5253-1MG
Informations supplémentaires : Poids : 0.00001kg
Description
Interleukin-2 receptor subunit beta (IL2RB) is also known as CD122, which Belongs to the type I cytokine receptor family. Type 4 subfamily. IL2RB contains 1 fibronectin type-III domain. IL2RB / CD122 is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.7 kDa. The protein migrates as 62-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spécification
| NP_000869.1 | |
| 1 mg | |
| Ala 27 - Asp 239 | |
| IL2RB,RP5-1170K4.6,CD122,P70-75 | |
| Unconjugated | |
| Fc Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 50.7 kDa | |
| Human IL-2 R beta, Fc Tag (SPR verified) (ILB-H5253) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Asp 239 (Accession # NP_000869.1). | |
| -20°C | |
| IL-2 R beta | |
| Human | |
| 50 mM Tris, 100 mM Glycine, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |