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ACROBiosystems Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free

Marque:  ACROBiosystems IT6-H52E1-1MG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15847157

  • 3850.90€ / 1mg
Expédition estimée: 09-02-2023
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Description

Description

Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency‐associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.

Human ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB6, has a calculated MW of 112.9 kDa (ITGAV) and 79.6 kDa (ITGB6). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhisti
Spécification

Spécification

NP_002201.1 (ITGAV) and AAI21179.1 (ITGB6)
112.9 kDa (ITGAV) and 79.6 kDa (ITGB6)
1 mg
Phe 31 - Val 992 (ITGAV) and Gly 22 - Asn 707 (ITGB6)
Integrin alpha V beta 6,ITGAVandITGB6
Unconjugated
50 mM Tris, 150 mM NaCl, pH7.5
HEK293
Human
Powder
>95% as determined by SDS-PAGE
Human ITGAV&ITGB6; Heterodimer Protein, His Tag&Tag; Free (IT6-H52E1) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 992 (ITGAV) and Gly 22 - Asn 707 (ITGB6) (Accession # NP_002201.1 (ITGAV) and AAI21179.1 (ITGB6)).
-20°C
Integrin alpha V beta 6
His Tag
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Vidéos
FDS
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Documents

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