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ACROBiosystems Human Osteoprotegerin / TNFRSF11B Protein, Fc Tag

Marque:  ACROBiosystems TNB-H5259-1MG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15867847

  • 1210.55€ / 1mg
Date d’expédition estimée: 28-12-2021

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Description

Description

Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 70.2 kDa. The protein migrates as 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spécification

Spécification

NP_002537
HEK293
Human
70.2 kDa
1 mg
Glu 22 - Leu 401
TNFRSF11B,OCIF,OPG,Osteoprotegerin
Unconjugated
50 mM Tris, 100 mM Glycine, pH7.5
Less than 1.0 EU / µg by the LAL method.
Other Recombinant Proteins
Powder
>92% as determined by SDS-PAGE
Human Osteoprotegerin, Fc Tag (TNB-H5259) is expressed from human 293 cells (HEK293). It contains AA Glu 22 - Leu 401 (Accession # NP_002537).
-20°C
Osteoprotegerin
Fc Tag
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