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ACROBiosystems Human P-Selectin / CD62P Protein, Fc Tag

Marque:  ACROBiosystems SEP-H5255-100UG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15867677

  • 262.28€ / 100µg
Date d’expédition estimée: 10-01-2022

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Description

Description

P-selectin (SELP) is also known as CD62 antigen-like family member P, granule membrane protein 140 (GMP-140), leukocyte-endothelial cell adhesion molecule 3 (LECAM3) and platelet activation dependent granule-external membrane protein (PADGEM). SELP functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets SELP is stored in α-granules. The primary ligand for SELP is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all leukocytes, although P-selectin also binds to heparan sulfate and fucoidan. Furthermore, SELP has a functional role in metastasis of tumor similar to E-selectin, which can help cancer cells invade into bloodstream for metastasis and provided locally with multiple growth factors respectively.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 106.6 kDa. The protein migrates as 146-160 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
Spécification

Spécification

AAN06828
HEK293
Human
106.6 kDa
100 µg
Trp 42 - Ala 771
P-Selectin,CD62P,SELP,GMP-140
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Human P-Selectin, Fc Tag (SEP-H5255) is expressed from human 293 cells (HEK293). It contains AA Trp 42 - Ala 771 (Accession # AAN06828).
-20°C
P-Selectin
Fc Tag
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