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ACROBiosystems Human PD-1 / PDCD1 Protein, His Tag, low endotoxin
MALS verified
556.44€ - 3229.78€
Spécification
Numéro d’adhésion | NP_005009.2 |
---|---|
Poids moléculaire | 16.8 kDa |
Source | Human PD-1, His Tag, low endotoxin (PD1-H522a) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Gln 167 (Accession # NP_005009.2). |
Immunogène | Leu 25 - Gln 167 |
Conditions de stockage | -20°C |
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
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Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
16457949
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ACROBiosystems
PD1-H522A-100UG |
100 μg |
556.44€
100µg |
Expédition estimée: 30-04-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
15867457
|
ACROBiosystems
PD1-H522A-1MG |
1 mg |
3229.78€
1mg |
Expédition estimée: 30-04-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
Description
Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.
This protein carries a polyhistidine tag at the C-terminus, and has a calculated MW of 16.8 kDa. The N-terminus Sequence Analysis is Leu 25. The reducing (R) protein migrates as 31-44 kDa in SDS-PAGE due to glycosylation.Spécification
NP_005009.2 | |
Human PD-1, His Tag, low endotoxin (PD1-H522a) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Gln 167 (Accession # NP_005009.2). | |
-20°C | |
PD-1 | |
Human | |
PBS, pH7.4 | |
HEK293 | |
Immune Checkpoint Proteins |
16.8 kDa | |
Leu 25 - Gln 167 | |
PDCD1,PD1,CD279,SLEB2 | |
Unconjugated | |
His Tag | |
Less than 0.01 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |