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ACROBiosystems Human RANK / TNFRSF11A Protein, Mouse IgG2a Fc Tag, low endotoxin

MALS verified

Marque:  ACROBiosystems RAK-H5251-1MG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15867577

  • 2118.47€ / 1mg
Date d’expédition estimée: 29-12-2021

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Description

Description

RANK / TNFRSF11A is a member of the tumor necrosis factor receptor family. RANK / TNFRSF11A shares significant amino acid homology with other members of the TNF R family in its extracellular four cysteine-rich repeats. Functional genomics in mice showed that RANKL (TNFSF11), a member of the TNF ligand superfamily, and RANK (TNFRSF11a), the cognate TNFR family receptor for RANKL, were essential for osteoclastogenesis in vivo. A functional interaction between RANKL, expressed by bone stromal cells of the osteoblast lineage, and RANK, expressed by osteoclast precursors of hematopoietic myeloid lineage, is necessary for osteoclast differentiation, survival, and activation.

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 47.2 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spécification

Spécification

NP_003830.1
HEK293
Human
47.2 kDa
1 mg
Ile 30 - Pro 212
CD265,FEO,LOH18CR1,ODFR,OFE,OPTB7,OSTS,PDB2,RANK,TNFRSF11A,TRANCER,CD265 antigen,ODFROSTS,RANKLOH18CR1,NFKB activator
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
Less than 0.1 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Human RANK, Mouse IgG2a Fc Tag, low endotoxin (RAK-H5251) is expressed from human 293 cells (HEK293). It contains AA Ile 30 - Pro 212 (Accession # Q9Y6Q6-1).
-20°C
RANK
Mouse IgG Fc Tag
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