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ACROBiosystems Human TIGIT Protein, Mouse IgG2a Fc Tag, low endotoxin

low endotoxin

Marque:  ACROBiosystems TIT-H5253-1MG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15857777

  • 3083.12€ / 1mg
Expédition estimée: 08-02-2023
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Description

Description

TIGIT (also called T cell immunoreceptor with Ig and ITIM domains) is one newly discovered immune receptor on some percentage of T cells and Natural Killer Cells(NK). It is also identified as WUCAM and Vstm3. TIGIT could bind to CD155(PVR) on dendritic cells(DCs), macrophages, etc. with high affinity, and also to CD112(PVRL2) with lower affinity. TIGIT expressing CD8+ T cells has been shown to be expanded and associated with clinical markers of HIV disease progression in a diverse group of HIV infected individuals. TIGIT and PD-1 has been shown to be over expressed on tumor antigen-sepcific (TA-specific) CD8+ T cells and CD8+ tumor infiltrating lymphocytes (TILs) from individuals with melanoma. Blockade of TIGIT and PD-1 led to increased cell proliferation, cytokine production, and degranulation of TA-specific CD8+ T cells and TIL CD8+ T cells.

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.1 kDa. The protein migrates as 42-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spécification

Spécification

AAI01290.1
40.1 kDa
1 mg
Met 22 - Pro 141
TIGIT,VSIG9,VSTM3
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Human
Powder
>95% as determined by SDS-PAGE
Human TIGIT, Mouse IgG2a Fc Tag (TIT-H5253) is expressed from human 293 cells (HEK293). It contains AA Met 22 - Pro 141 (Accession # Q495A1-1).
-20°C
TIGIT
Mouse IgG Fc Tag
Less than 0.1 EU / µg by the LAL method.
Immune Checkpoint Proteins
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