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ACROBiosystems Human TIM-3 / HAVCR2 (22-200) Protein, Fc Tag

443.87€ - 2771.21€

Spécification

Numéro d’adhésion NP_116171.3
Poids moléculaire 46.5 kDa
Source Human TIM-3, Fc Tag (TM3-H5258) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Arg 200 (Accession # Q8TDQ0-1).
Immunogène Ser 22 - Arg 200
Conditions de stockage -20°C
Consulter d'autres spécifications

Produits 2
Code produit Marque Quantité Prix Quantité et disponibilité  
Code produit Marque Quantité Prix Quantité et disponibilité  
15847797
Afficher les documents Détails de la promotion
ACROBiosystems
TM3-H5258-100UG
100 μg
443.87€
100µg
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Expédition estimée: 11-04-2024
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15857797
Afficher les documents Détails de la promotion
ACROBiosystems
TM3-H5258-1MG
1 mg
2771.21€
1mg
Voir les produits de remplacement
Économisez jusqu'à 
»
Expédition estimée: 11-04-2024
pour voir le stock disponible 
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Description

Description

Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 46.5 kDa. The protein migrates as 60-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spécification

Spécification

NP_116171.3
Human TIM-3, Fc Tag (TM3-H5258) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Arg 200 (Accession # Q8TDQ0-1).
-20°C
TIM-3
Human
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Immune Checkpoint Proteins
46.5 kDa
Ser 22 - Arg 200
HAVCR2,TIM3,TIMD3,FLJ14428,KIM3
Unconjugated
Fc Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>85% as determined by SDS-PAGE
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FDS
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