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ACROBiosystems Human UCH-L3 / UCHL3 Protein, His Tag
314.52€ - 1959.64€
Spécification
| Numéro d’adhésion | AAH18125.1 |
|---|---|
| Poids moléculaire | 27.0 kDa |
| Source | Human UCH-L3, His Tag (UC3-H5141) is expressed from E.coli cells. It contains AA Glu 2 - Ala 230 (Accession # P15374-1). |
| Immunogène | Glu 2 - Ala 230 |
| Conditions de stockage | -20°C |
| Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
|---|---|---|---|---|---|---|---|---|---|
| Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
|
15887887
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ACROBiosystems
UC3-H5141-1MG |
1 mg |
1959.64€
1mg |
Expédition estimée: 02-05-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
|
15877887
|
ACROBiosystems
UC3-H5141-100UG |
100 μg |
314.52€
100µg |
Expédition estimée: 02-05-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
Description
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3), a member of peptidase C12 family, is also known as ubiquitin thioesterase L3. Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. UCH-L3 is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. UCH-L3 indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. It is also required for stress-response retinal, skeletal muscle and germ cell maintenance. Furthermore, UCH-L3 may be involved in working memory and can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 27.0 kDa. The protein migrates as 27 kDa under reducing (R) condition (SDS-PAGE).Spécification
| AAH18125.1 | |
| Human UCH-L3, His Tag (UC3-H5141) is expressed from E.coli cells. It contains AA Glu 2 - Ala 230 (Accession # P15374-1). | |
| -20°C | |
| UCH-L3 | |
| Human | |
| 50 mM Tris, 150 mM NaCl, pH7.5 | |
| E.coli | |
| Enzymes |
| 27.0 kDa | |
| Glu 2 - Ala 230 | |
| UCHL3,Ubiquitin thioesterase L3 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |