missing translation for 'onlineSavingsMsg'
Learn More

ACROBiosystems Human UCH-L3 / UCHL3 Protein, His Tag

Marque:  ACROBiosystems UC3-H5141-100UG

Informations supplémentaires : Poids : 0.00001kg

 Afficher plus de versions de ce produit

Code produit. 15877887

  • 262.28€ / 100µg
Date d’expédition estimée: 10-01-2022

Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!


Description

Description

Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3), a member of peptidase C12 family, is also known as ubiquitin thioesterase L3. Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. UCH-L3 is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. UCH-L3 indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. It is also required for stress-response retinal, skeletal muscle and germ cell maintenance. Furthermore, UCH-L3 may be involved in working memory and can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 27.0 kDa. The protein migrates as 27 kDa under reducing (R) condition (SDS-PAGE).
Spécification

Spécification

AAH18125.1
E.coli
Human
27.0 kDa
100 µg
Glu 2 - Ala 230
UCHL3,Ubiquitin thioesterase L3
Unconjugated
50 mM Tris, 150 mM NaCl, pH7.5
Less than 1.0 EU / µg by the LAL method.
Enzymes
Powder
>95% as determined by SDS-PAGE
Human UCH-L3, His Tag (UC3-H5141) is expressed from E.coli cells. It contains AA Glu 2 - Ala 230 (Accession # P15374-1).
-20°C
UCH-L3
His Tag
Vidéos
FDS
Documents
Certificats
Promotions

Promotions