ICP27 Rabbit anti-Virus, Polyclonal, Proteintech

Description

There are two serotypes of the herpes simplex virus, HSV-1 (also known as type 1 or oral) and HSV-2 (type 2 or genital), can establish lifelong latent infections within sensory ganglia. Periodically, the virus reactivates and can cause re-current cold sores, eye and genital infections and encephalitis. One of the HSV-1/2 proteins involved in converting the cell into an efficient producer of viral gene products is the Infected Cell Polypeptide 27 or ICP27. HSV-1/2 immediate-early protein ICP27 is a nuclear phosphoprotein that is required for viral growth during lytic infection. Analysis of viral mutants defective in this function has shown that ICP27 has a number of effects on gene expression including a contribution to the shut off of host protein synthesis, the stimulation of HSV-1/2 early gene expression and DNA replication, and the induction of late viral gene products. ICP27 performs these functions primarily post-transcriptionally at the level of RNA processing. ICP27 affects three important RNA processing events: polyadenylation, splicing and nuclear RNA export.