Invitrogen™ JAK2 Monoclonal Antibody (1C1)

Description

MA5-15632 targets JAK2 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15632 immunogen is purified recombinant fragment of JAK2(745-955aa) expressed in E. Coli.. MA5-15632 detects JAK2 which has a predicted molecular weight of approximately 130.6kDa.

Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.