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LCK Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 24497-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16802975

  • 112.71€ / 20µL

Expédition estimée
09-03-2021

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Description

Description

LCK is a member of the Src-family tyrosine kinase, which are essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering, LCK phosphorylates the ITAM motives in its zeta subunits establishing binding sites for the SH2 domains of the tyrosine kinase ZAP70, which is also phosphorylated by LCK and activated to generate subsequent signaling platforms by phosphorylation of adaptor LAT. The majority of LCK is localized to the plasma membrane, however, there is also a significant fraction associated with the Golgi apparatus which may contribute to Raf activation under conditions of weak stimulation through the TCR. LCK contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. LCK is also involved in the regulation of apoptosis induced by various stimuli, but not by the death receptors. Diseases associated with LCK include Immunodeficiency 22 and CD45 deficiency. Alternatively splice variants of the LCK gene encoding different isoforms of the protein have been found.
Spécification

Spécification

LCK
0.51 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P06239, P06240
LCK, LSK, p56 LCK, p56lck, pp58lck, Protein YT16, Proto oncogene Lck, Tyrosine protein kinase Lck, YT16
Rabbit
IgG
20 μL
-20°C
Primary
16818, 3932
Western Blot
Unconjugated
LCK
Liquid
LCK
LCK Fusion Protein Ag21475
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Mouse, Human
Vidéos
FDS
Documents