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MCU/CCDC109A Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 26312-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16804825

  • 112.71€ / 20µL

Expédition estimée
26-02-2021

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Description

Description

Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a ′fight-or-flight′ response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells. participates in mitochondrial permeability transition during ischemia-reperfusion injury. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults. Regulates synaptic vesicle endocytosis kinetics in central nerve terminal. Involved in antigen processing and presentation.
Spécification

Spécification

MCU/CCDC109A
0.35 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q8NE86
C10orf42, Calcium uniporter protein, CCDC109A, MCU
Rabbit
IgG
20 μL
-20°C
Primary
90550
Immunofluorescence, Immunocytochemistry, Western Blot
Unconjugated
MCU
Liquid
MCU
MCU/CCDC109A Fusion Protein Ag24733
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Vidéos
FDS
Documents