missing translation for 'onlineSavingsMsg'
Learn More

MKNK2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 17354-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

 Afficher plus de versions de ce produit

Code produit. 16827234

  • 121.38€ / 20µL
Expédition estimée: 30-09-2022
pour voir le stock disponible 

Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!


Description

Description

MAP kinase-interacting kinase 1 (Mnk1) and Mnk2, members of the Ser/Thr protein kinase family, bind tightly to the growth factor-regulated MAP kinases, Erk1 and Erk2. Erk and p38 phosphorylate MNK1 and Mnk2, which stimulates their in vitro kinase activity toward a substrate, eukaryotic initiation factor-4E (eIF-4E). Overexpression of Mnk2 results in increased phosphorylation of endogenous eIF-4E, showing that it can act as an eIF-4E kinase in vivo. Mnk2 may play a role in the response to environmental stress and cytokines. This ubiquitiously expressed protein appears to regulate transcription by phosphorylating eIF-4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Expression of active mutants of MNK1 and MNK2 in 293 cells diminishes cap-dependent translation relative to cap-independent translation in a transient reporter assay. Human Mnk2 is homologous to murine Mnk2 (approximately 94% identical) and human Mnk1 (71% identical). In vitro phosphorylation studies show that Mnk2 is a significantly better substrate than Mnk1 for extracellular signal-regulated kinase 2 (Erk2), p38MAPKalpha, and p38MAPKbeta. Mnk2 has also been shown to interact with the C-terminal regions of eIF-4G1 and eIF-4G2.
Spécification

Spécification

MKNK2
Polyclonal
Unconjugated
MKNK2
GPRK7, MKNK2, MNK2
Rabbit
Antigen Affinity Chromatography
RUO
17347, 2872, 299618
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Immunofluorescence
0.2 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q5U2N4, Q8CDB0, Q9HBH9
MKNK2
MKNK2 Fusion Protein Ag10546
20 μL
Primary
Rat, Mouse, Human
Antibody
IgG
Vidéos
FDS
Documents
Certificats
Promotions

Promotions