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MLL5 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 14540-1-AP-150UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16803234

  • 329.85€ / 150µL

Expédition estimée
02-03-2021

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Description

Description

The mixed lineage leukemia (MLL) gene family comprise a group of Histone H3 lysine 4 (H3K4) methyltransferases within the larger SET1 family. The founding member MLL commonly undergoes translocations in infantile leukemia and displays increased expression in some adult myeloid leukemias. MLL2, also designated ALR, exists within a complex of proteins. MLL2 is important for mouse embryonic development and may be involved in adhesion-related cytoskeletal events affecting cell growth and survival. The MLL2 gene maps to the human locus 19q13.1, which is a frequent target of rearrangement or amplification in solid tumors. MLL3 or its paralogue MLL4 associate with activating signal cointegrator-2 (ASC-2), which regulates ligand-dependent H3K4 trimethylation and expression of LXR-target genes. MLL3 maps to a location on human chromosome 7 that is often deleted in myeloid disorders. MLL3 also exhibits higher expression in peripheral blood, placenta, pancreas, testis, and fetal thymus. MLL5 localizes to the nucleus and forms intranuclear protein complexes, which may regulate chromatin remodeling and cellular growth suppression. The gene encoding human MLL5 lies within chromosome band 7q22.3, a region deleted in cytogenetic aberrations of acute myeloid maligcies.
Spécification

Spécification

MLL5
0.27 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q3UG20, Q8IZD2
HDCMC04P, KMT2E, Lysine N methyltransferase 2E, MLL5
Rabbit
IgG
150 μL
-20°C
Primary
55904, 69188
Immunocytochemistry, Immunofluorescence, Western Blot
Unconjugated
KMT2E
Liquid
KMT2E
MLL5 Fusion Protein Ag6044
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Vidéos
FDS
Documents