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ACROBiosystems Mouse SIRP alpha / CD172a Protein, Mouse IgG2a Fc Tag, low endotoxin
low endotoxin
350.80€ - 2661.24€
Spécification
Numéro d’adhésion | BAA13520.1 (G365D) |
---|---|
Poids moléculaire | 65.0 kDa |
Source | Mouse SIRP alpha, Mouse IgG2a Fc Tag, low endotoxin (SIA-M5252) is expressed from human 293 cells (HEK293). It contains AA Lys 32 - Asn 373 (Accession # BAA13520.1 (G365D)). |
Immunogène | Lys 32 - Asn 373 |
Conditions de stockage | -20°C |
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
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Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
15877697
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ACROBiosystems
SIA-M5252-100UG |
100 μg |
350.80€
100µg |
Expédition estimée: 30-04-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
15887697
|
ACROBiosystems
SIA-M5252-1MG |
1 mg |
2661.24€
1mg |
Expédition estimée: 30-04-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
Description
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 65.0 kDa. The protein migrates as 90-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spécification
BAA13520.1 (G365D) | |
Mouse SIRP alpha, Mouse IgG2a Fc Tag, low endotoxin (SIA-M5252) is expressed from human 293 cells (HEK293). It contains AA Lys 32 - Asn 373 (Accession # BAA13520.1 (G365D)). | |
-20°C | |
SIRP alpha | |
Mouse | |
50 mM Tris, 100 mM Glycine, pH7.5 | |
HEK293 | |
Immune Checkpoint Proteins |
65.0 kDa | |
Lys 32 - Asn 373 | |
SHPS1,SIRPA,CD172A,BIT,MFR,MYD1,P84,PTPNS1 | |
Unconjugated | |
Mouse IgG Fc Tag | |
Less than 0.1 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |