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ACROBiosystems Mouse TIGIT Protein, His Tag

Marque:  ACROBiosystems TIT-M52E6-1MG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15867787

  • 1997.41€ / 1mg
Date d’expédition estimée: 10-01-2022

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Description

Description

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.8 kDa. The protein migrates as 18-30 kDa under reducing (R) condition (SDS-PAGE).
Spécification

Spécification

NP_001139797.1
HEK293
Mouse
14.8 kDa
1 mg
Gly 26 - Thr 143
TIGIT,VSIG9,VSTM3
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Immune Checkpoint Proteins
Powder
>90% as determined by SDS-PAGE
Mouse TIGIT, His Tag (TIT-M52E6) is expressed from human 293 cells (HEK293). It contains AA Gly 26 - Thr 143 (Accession # NP_001139797.1).
-20°C
TIGIT
His Tag
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