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ACROBiosystems Mouse TIM-3 / HAVCR2 Protein, Fc Tag

Marque:  ACROBiosystems TI3-M5252-100UG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15867767

  • 292.55€ / 100µg
Date d’expédition estimée: 03-01-2022

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Description

Description

Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 45.8 kDa. The protein migrates as 60-80 kDa under reducing (R) condition (SDS-PAGE).
Spécification

Spécification

AAL65156.1
HEK293
Mouse
45.8 kDa
100 µg
Arg 20 - Arg 191
HAVCR2,TIM3,TIMD3,FLJ14428,KIM3
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
Less than 1.0 EU / µg by the LAL method.
Immune Checkpoint Proteins
Powder
>90% as determined by SDS-PAGE
Mouse TIM-3, Fc Tag (TI3-M5252) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Arg 191 (Accession # AAL65156.1).
-20°C
TIM-3
Fc Tag
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