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Muskelin Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 14735-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16803534

  • 112.71€ / 20µL

Expédition estimée
02-03-2021

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Description

Description

MAP kinase-interacting serine/threonine kinases (Mnk) function in signal transduction pathways through phosphorylation of eIF4E and are directly phosphorylated by ERK or p38 MAP kinases. In human and mouse there are two Mnk genes. Mnk1 is activated by phosphorylation at Thr197 and Thr202. Mnk1 and Mnk2 are essential for the phosphorylation of eIF4E at Ser209 however they differ markedly in their activity and regulatory patterns. Mnk1 is responsible for inducible phosphorylation of eIF4E while Mnk2 is responsible for basal levels of phosphorylation. Mnk1 has been implicated in signaling in response to oxidative stress by increasing eIF4E phosphorylation upon H2O2 treatment in mice. Oxidative stress induced Mnk1 activity has also been linked to hyperproliferative diseases through the over-activation of eIF4E. Reactivity with Mnk2 has not been tested.
Spécification

Spécification

Muskelin
0.15 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O89050, Q99PV3, Q9UL63
MKLN1, Muskelin, TWA2
Rabbit
IgG
20 μL
-20°C
Primary
27418, 4289, 83536
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
MKLN1
Liquid
MKLN1
Muskelin Fusion Protein Ag6147
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Rat, Mouse
Vidéos
FDS
Documents