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Myh9 Rabbit anti-Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
140.00€ - 399.00€
Spécification
Antigène | Myh9 |
---|---|
Concentration | 0.6 mg/mL |
Applications | ELISA |
Classification | Polyclonal |
Conjugué | Unconjugated |
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
---|---|---|---|---|---|---|---|---|---|
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
16806335
|
Proteintech
51053-1-IG-20UL |
20 μL |
140.00€
20µL |
Expédition estimée: 06-05-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
16896325
|
Proteintech
51053-1-IG-150UL |
150 μL |
399.00€
150µL |
Expédition estimée: 06-05-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
Description
TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer′s disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.Spécification
Myh9 | |
ELISA | |
Unconjugated | |
Rabbit | |
Mouse | |
Q8VDD5 | |
17886 | |
Peptide | |
Primary | |
-20°C | |
Myh9 |
0.6 mg/mL | |
Polyclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
C80049, D0Jmb2, E030044M24Rik, Myh9, Myhn 1, Myhn1, TU72.6 | |
Myh9 | |
IgG | |
Protein A | |
Antibody |