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ORAI3 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 25766-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16804335

  • 112.71€ / 20µL

Expédition estimée
25-02-2021

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Description

Description

This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.

Antigen stimulation of immune cells triggers Ca++ entry t through Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.
Spécification

Spécification

ORAI3
0.27 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q6P8G8, Q9BRQ5
ORAI3, Protein orai 3, TMEM142C, Transmembrane protein 142C
Rabbit
IgG
20 μL
-20°C
Primary
269999, 93129
Western Blot, Immunohistochemistry (Paraffin)
Unconjugated
ORAI3
Liquid
ORAI3
ORAI3 Fusion Protein Ag22513
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Vidéos
FDS
Documents