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ORAI3 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marque: Proteintech 25766-1-AP-20UL
Informations supplémentaires : Poids : 0.00010kg
Description
This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.
Antigen stimulation of immune cells triggers Ca++ entry t through Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.Spécification
ORAI3 | |
Polyclonal | |
Unconjugated | |
ORAI3 | |
ORAI3, Protein orai 3, TMEM142C, Transmembrane protein 142C | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
269999, 93129 | |
-20°C | |
Liquid |
Western Blot, Immunohistochemistry (Paraffin) | |
0.27 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
Q6P8G8, Q9BRQ5 | |
ORAI3 | |
ORAI3 Fusion Protein Ag22513 | |
20 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |