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PREB Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marque: Proteintech 10146-2-AP-20UL
Informations supplémentaires : Poids : 0.00010kg
Description
Prolactin (PRL) expression in the pituitary is limited to specific cells. Pit-1 is a pituitary specific transcription factor that plays an important role in PRL expression, both in mature organism and during development. The PRL promoter contains numerous Pit-1 binding sites and these sites have been implicated in both basal level and kinase-mediated gene expression. The most proximal of these binding sites, termed 1P, has been shown to direct a response to numerous signals, such as cAMP and various G-proteins. A novel protein, termed PREB (prolactin regulatory element binding protein), has been recently identified that regulates PRL gene expression through the 1P site, though it contains no discernable DNA-binding motif. Recent studies suggest that PREB is encoded by a single-copy gene in both mice and humans and exhibits nuclear accumulation in pituitary cells. Evidence suggests that PREB is a novel transcription factor that assists in PRL expression whether alone, or in concert with Pit-1.Spécification
PREB | |
Polyclonal | |
Unconjugated | |
PREB | |
PREB, SEC12 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
10113, 50907 | |
-20°C | |
Liquid |
Immunoprecipitation, Immunocytochemistry, Western Blot, Immunofluorescence, Immunohistochemistry (Paraffin) | |
0.39 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
Q9HCU5, Q9WUQ2 | |
Preb | |
PREB Fusion Protein Ag0202 | |
20 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |