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PTRH2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 51006-2-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16806265

  • 112.71€ / 20µL

Expédition estimée
03-03-2021

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Description

Description

The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency. Alternative splicing results in multiple transcript variants encoding different isoforms.
Spécification

Spécification

PTRH2
0.2 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q8R2Y8, Q9Y3E5
BIT1, CGI 147, peptidyl tRNA hydrolase 2, PTH 2, PTH2, PTRH2
Rabbit
IgG
20 μL
-20°C
Primary
217057, 287593, 51651
Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry, Western Blot
Unconjugated
PTRH2
Liquid
Ptrh2
PTRH2 Fusion Protein Ag0839
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Rat, Human, Mouse
Vidéos
FDS
Documents