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PTRH2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

140.00€ - 399.00€

Spécification

Antigène PTRH2
Concentration 0.2 mg/mL
Applications Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry, Western Blot
Classification Polyclonal
Conjugué Unconjugated
Consulter d'autres spécifications

Produits 2
Code produit Marque Quantité Prix Quantité et disponibilité  
Code produit Marque Quantité Prix Quantité et disponibilité  
16806265
Afficher les documents Détails de la promotion
Proteintech
51006-2-AP-20UL
20 μL
140.00€
20µL
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Économisez jusqu'à 
»
Expédition estimée: 12-04-2024
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16896255
Afficher les documents Détails de la promotion
Proteintech
51006-2-AP-150UL
150 μL
399.00€
150µL
Voir les produits de remplacement
Économisez jusqu'à 
»
Expédition estimée: 12-04-2024
pour voir le stock disponible 
Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!
Description

Description

The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency. Alternative splicing results in multiple transcript variants encoding different isoforms.
Spécification

Spécification

PTRH2
Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry, Western Blot
Unconjugated
Rabbit
Rat, Human, Mouse
Q8R2Y8, Q9Y3E5
217057, 287593, 51651
PTRH2 Fusion Protein Ag0839
Primary
-20°C
PTRH2
0.2 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
BIT1, CGI 147, peptidyl tRNA hydrolase 2, PTH 2, PTH2, PTRH2
Ptrh2
IgG
Antigen Affinity Chromatography
Antibody
Vidéos
FDS
Documents

Documents

Product Certifications