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SCF Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marque: Proteintech 26582-1-AP-20UL
Informations supplémentaires : Poids : 0.00010kg
Description
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.Spécification
SCF | |
Polyclonal | |
Unconjugated | |
KITLG | |
c Kit ligand, KIT ligand, Kitl, KITLG, KL 1, Mast cell growth factor, MGF, SCF, SF, SHEP7, Stem cell factor | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
17311, 4254 | |
-20°C | |
Liquid |
Western Blot, Immunohistochemistry (Paraffin) | |
0.27 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
P20826, P21583 | |
Kitlg | |
SCF Fusion Protein Ag25075 | |
20 μL | |
Primary | |
Mouse, Human | |
Antibody | |
IgG |