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SCF Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 26582-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16805005

  • 112.71€ / 20µL

Expédition estimée
09-03-2021

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Description

Description

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
Spécification

Spécification

SCF
0.27 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P20826, P21583
c Kit ligand, KIT ligand, Kitl, KITLG, KL 1, Mast cell growth factor, MGF, SCF, SF, SHEP7, Stem cell factor
Rabbit
IgG
20 μL
-20°C
Primary
17311, 4254
Western Blot, Immunohistochemistry (Paraffin)
Unconjugated
KITLG
Liquid
Kitlg
SCF Fusion Protein Ag25075
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Mouse, Human
Vidéos
FDS
Documents