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SPIB Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marque: Proteintech 15768-1-AP-150UL
Informations supplémentaires : Poids : 0.00010kg
Description
Spi-B is a transcription factor belonging to a subfamily of ETS transcription factors with a conserved ETS domain that mediates specific DNA binding. Spi-B may form homotypic interactions and is known to interact with IRF4, CREBBP, EP300, SPI1/PU.1 related, JUN and TBP. As a sequence specific transcriptional activator it binds to the PU-box, a purine-rich DNA sequence (5′-GAGGAA-3′) that can act as a lymphoid-specific enhancer. Two isoforms of Spi-B are reported. Spi-B is usually expressed in plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells and promotes their development and block viral replication. Spi-B is not expressed in T-cells or granulocytes but may be present in stem cell populations of the liver and B-cells where it helps in B-cell receptor (BCR) signaling, normal B-cell development and antigenic stimulation.Spécification
SPIB | |
Polyclonal | |
Unconjugated | |
SPIB | |
SPI B, SPIB, Transcription factor Spi B | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
272382, 499146, 6689 | |
-20°C | |
Liquid |
Immunoprecipitation, Western Blot | |
0.25 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
O35906, Q01892, Q5EBA3 | |
Spib | |
SPIB Fusion Protein Ag8404 | |
150 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |