T-bet Mouse anti-Human, Mouse, Rhesus Monkey, eFluor® 660, Clone: eBio4B10 (4B10), eBioscience™
Mouse Monoclonal Antibody
Marque: Affymetrix eBioscience 50-5825-80
Code nomenclature Nacres: NA.41
Informations supplémentaires : Poids : 0.25000kg
DescriptionIt is recommended to use the Foxp3/Transcription Factor Staining Buffer Set (cat. 00-5523) and protocol. Refer to Best Protocols for Staining Protocol (Protocol B: One step protocol for intracellular (nuclear) proteins) eFluor® 660 is a replacement for Alexa Fluor® 647. eFluor® 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome. Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered. T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|T-PET, T-bet, TBET, TBLYM, T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; transcription factor TBLYM|
|Human, Mouse, Rhesus Monkey|
|4° C, store in dark, DO NOT FREEZE!|
|30009, 57765, 694044|
For Research Use Only.