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TREX1 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 24876-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16803385

  • 112.71€ / 20µL

Expédition estimée
25-02-2021

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Description

Description

Trex1 (ATRIP) is the major human 3′ to 5′ exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3′ to 5′ exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.
Spécification

Spécification

TREX1
0.35 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q9NSU2
3 5 exonuclease TREX1, AGS1, AGS5, CRV, DNase III, DRN3, HERNS, TREX1
Rabbit
IgG
20 μL
-20°C
Primary
11277
Western Blot, Immunoprecipitation
Unconjugated
TREX1
Liquid
TREX1
TREX1 Fusion Protein Ag18325
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Vidéos
FDS
Documents