VEGFR3 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marque: Proteintech 20712-1-AP-20UL
Informations supplémentaires : Poids : 0.00010kg
The antibody is specific to FLT4.Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.
|FLT 4, FLT4, FLT41, Fms like tyrosine kinase 4, fms related tyrosine kinase 4, LMPH1A, PCL, VEGFR 3, VEGFR3|
|Antigen Affinity Chromatography|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|