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IDO1 Mouse anti-Human, Clone: UMAB126, liquid, UltraMAB™

Product Code. 17579724
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Quantity:
30 μL
Unit Size:
30µL
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Product Code. Quantity Unit Size
17579724 30 μL 30µL
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Product Code. 17579724 Supplier Origene Technologies Supplier No. UM570091
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Expédition estimée: 07-12-2026
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Descrizione

Mouse Monoclonal Antibody

IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules like tryptophan, serotonin, and melatonin. By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines. IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs). In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction. The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms. Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites. Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregcy, autoimmunity, transplantation, and neoplasia.

Specifica

Antigen IDO1
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone UMAB126
Concentration 0.5-1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene IDO1
Gene Accession No. P14902
Gene Alias IDO, IDO-1, INDO
Gene Symbols IDO1
Host Species Mouse
Immunogen Full length human recombit protein of human IDO1 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 30 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3620
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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