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  6. Thermo Scientific Chemicals (R,R)-Chloramphenicol, 98%

Thermo Scientific Chemicals (R,R)-Chloramphenicol, 98%

Artikelnummer. 11455786
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Regulatorisk: Dette produkt falder ind under Lov om kemiske stoffer og produkter - lovbekendtgørelse nr. 1755 af 22. december 2006. Hvis det er relevant, skal kunden fremskaffe en licens før levering.
Artikelnummer. 11455786 Leverandør Thermo Scientific Chemicals Leverandørnr. B20841.22
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Denne vare kan ikke returneres. Se returpolicy
Regulatorisk: Dette produkt falder ind under Lov om kemiske stoffer og produkter - lovbekendtgørelse nr. 1755 af 22. december 2006. Hvis det er relevant, skal kunden fremskaffe en licens før levering.

Beskrivelse

(R,R)-Chloramphenicol, CAS # 56-75-7, also known as chloromycetin, is a compound with broad-spectrum antibiotic and bacteriostatic activities. | CAS: 56-75-7 | C11H12Cl2N2O5 | 323.126 g/mol

Inhibitor of translation on the 50S subunit at the peptidyltransferase step. (R,R)-Chloramphenicol is widely utilized as an antibiotic, which is used for the treatment of number of bacterial infections and also act as a bacteriostatic. It is often used for bacterial selection in molecular biology applications. It also finds an application in ophthalmic and veterinary purposes. It also protects the mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • (R,R)-chloramphenicol is a compound with antibiotic and bacteriostatic activity and is derived from Streptomyces venequelae
  • It that can block the translation on the 50S subunit at the peptidyltransferase step. The binding affects the peptidyl transferase activity, preventing the transfer of amino acids to the growing peptide chains and inhibiting peptide bond formation. The resulting inhibition of the bacterial protein synthesis impedes bacterial cell proliferation

Application

  • (R,R)-chloramphenicol has been used for several molecular biology approaches, mainly for bacterial selection. It can be used to select transformed cells containing chloramphenicol resistance genes
  • This compound can also promote mitochondrial and chloroplast protein synthesis and the ribosomal formation of (p)ppGpp, depressing the rRNA transcription process
  • In vitro results demonstrate that (R,R)-chloramphenicol shows activity against several vancomycin-resistant E. faecium strains
TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 56-75-7
Molecular Formula C11H12Cl2N2O5
Molecular Weight (g/mol) 323.126
MDL Number MFCD00078159
InChI Key WIIZWVCIJKGZOK-RKDXNWHRSA-N
Synonym Chloromycetin
PubChem CID 5959
ChEBI CHEBI:17698
IUPAC Name 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
SMILES C1=CC(=CC=C1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]

Tekniske data

Type (R,R)-Chloramphenicol
Physical Form Crystalline Powder
Melting Point 149°C to 152°C
Color Cream to White
Quantity 100 g
Assay Percent Range 0.99
Beilstein 2225532
Merck Index 14,2077
Solubility Information Soluble in alcohol,propylene,glycol,acetone and ethyl acetate. Slightly soluble in water.
Formula Weight 323.14
Percent Purity ≥99%
Chemical Name or Material (R,R)-Chloramphenicol
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Sikkerhed og håndtering

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Produktidentifikator
  • (R,R)-Chloramphenicol
 Signalord
  • Danger
 Farekategori
  • Carcinogenicity Category 1B
 Faresætning
  • H350-May cause cancer.
 Sikkerhedssætning
  • P201-Obtain special instructions before use.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.
 Supplerende oplysninger
  • MIXTURE LIST-Contain: Chloramphenicol
SDS

RUO – Research Use Only

Produkttitel
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