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Candesartan, 98%

Code produit 15405129
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Quantité:
100 mg
1 g
Conditionnement:
100mg
1g
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Code produit Quantité Conditionnement
15405129 100 mg 100mg
15495119 1 g 1g
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Code produit 15405129 Fournisseur Thermo Scientific Alfa Aesar Code fournisseur J62818.MC
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Descrizione

Angiotensin II receptor antagonist | CAS: 139481-59-7 | C24H20N6O3 | 440.463 g/mol

Candesartan is a selective AT1 (angiotensin II receptor 1) antagonist. Antagonism of angiotensin receptors inhibits vasoconstriction and the production of aldosterone, leading to a decrease in water and sodium concentration in blood plasma. Exhibits antihypertensive effects in animal models. Used in treatment of congestive heart failure, as antihypertensive. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in ethyl acetate, methanol, water (<1mg/mL at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).

Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 139481-59-7
Formule moléculaire C24H20N6O3
Poids moléculaire (g/mol) 440.463
Numéro MDL MFCD00081076
Clé InChI HTQMVQVXFRQIKW-UHFFFAOYSA-N
Synonyme candesartan, blopress, ratacand, 1-2'-1h-tetrazol-5-yl-1,1'-biphenyl-4-yl methyl-2-ethoxy-1h-benzo d imidazole-7-carboxylic acid, candesartan ban, 3h candesartan, unii-s8q36md2xx, 2-ethoxy-3-4-2-2h-tetrazol-5-yl phenyl phenyl methyl benzimidazole-4-carboxylic acid, candesartan usan/inn, candesartan usan:inn
CID PubChem 2541
ChEBI CHEBI:3347
Nom IUPAC 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid
SMILES CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)O

Specifica

Nom chimique ou matériau Candesartan
Point de fusion 183°C to 185°C
Couleur Blanc
Quantité 100 mg
Merck Index 14,1739
Informations sur la solubilité Soluble in ethyl acetate,methanol,water (<1mg/ml at 25°C),DMSO (88mg/ml at 25°C),and ethanol (1mg/ml at 25°C).
Poids de la formule 440.45
Pourcentage de pureté 98%
Forme physique Powder

Sicurezza e movimentazione

compliance-icons
Identificativo prodotto
  • Candesartan
 Avvertenza
  • Attention
 Categoria di pericolo
  • Toxicité pour la reproduction Catégorie 2
 Indicazioni di pericolo
  • H361d-Susceptible de nuire au foetus.
 Consigli di prudenza
  • P201-Se procurer les instructions avant utilisation.
  • P280-Porter des gants de protection/des vêtements de protection/un équipement de protection des yeux/ du visage.
  • P308+P313-EN CAS d'exposition prouvée ou suspectée: consulter un médecin.
 Informazioni supplementari
  • MIXTURE LIST-Contain: Candesartan
SDS

RUO – Research Use Only

Titolo del prodotto
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