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Invitrogen™ Human DNA-PK Native Protein

Code produit 15378517
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Quantité:
1 mg
Conditionnement:
1 pièce
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Code produit Quantité unitSize
15378517 1 mg 1 pièce
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Code produit 15378517 Fournisseur Invitrogen™ Code fournisseur PV5865

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Description

Native Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Native human protein purified from MOLT-4 cells. No special measures were taken to activate this kinase. Protein Form: Full Length

DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for DNA-PK.
TRUSTED_SUSTAINABILITY

Spécification

Numéro d’adhésion P78527
Concentration Conc. Not Determined
À utiliser avec (application) Kinase Assay
Formule 25 mM HEPES with 0.2 mM EDTA, 10% glycerol, 10 mM MgCl2, 1 mM DTT, 50 mM KCl and no preservative; pH 7.5
Identification génétique (Entrez) 5591
Poids moléculaire 600 kDa
Nom Human DNA-Pk.
Quantité 1 mg
État réglementaire RUO - research use only
Alias de gène AI326420; AU019811; DNA-dependent protein kinase catalytic subunit; DNAPDcs; DNAPK; DNA-Pk. catalytic subunit; DNA-PKcs; DNPK1; DOXNPH; doxorubicin nephropathy; dxnph; hyper-radiosensitivity of murine scid mutation, complementing 1; HYRC; HYRC1; I79_017613; IMD26; p350; p460; Prkdc; protein kinase, DNA activated, catalytic polypeptide; protein kinase, DNA-activated, catalytic polypeptide; scid; severe combined immunodeficiency; slip; Xrcc7
Nom usuel DNA-Pk.
Famille des kinases PIKK Kinase Family
Conjugué Unconjugated
Espèces Human
Séquence Full length
Contenu et stockage -80°C, Avoid Freeze/Thaw Cycles
Forme Liquid
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