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Etoposide

Code produit 15495819
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100 mg
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15495819 25 mg 25mg
15405829 100 mg 100mg
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Code produit 15495819 Fournisseur Thermo Scientific Alfa Aesar Code fournisseur J63651.MB
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Description

Topoisomerase inhibitor and inducer of apoptosis | CAS: 33419-42-0 | C29H32O13 | 588.56 g/mol

Etoposide is used as a inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53-/-) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Etoposide is used as a inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53-/-) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.

Solubility
Insoluble in water.

Notes
Store solutions in DMSO at 4°C. For long term storage prepare aliquots and store at -20°C.
TRUSTED_SUSTAINABILITY

Identifiants chimiques

CAS 33419-42-0
Formule moléculaire C29H32O13
Poids moléculaire (g/mol) 588.56
Numéro MDL MFCD00869325,MFCD00869325
Clé InChI VJJPUSNTGOMMGY-MRVIYFEKSA-N
Synonyme vjjpusntgommgy-nzlmilqcsa
CID PubChem 50936917
Nom IUPAC (10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,⁷.0¹¹,¹⁵]hexadeca-1,3(7),8-trien-12-one
SMILES COC1=CC(=CC(OC)=C1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@@H](C)O[C@H]3[C@H](O)[C@H]2O)C2=CC3=C(OCO3)C=C12

Spécification

Nom chimique ou matériau Etoposide
Point de fusion 236°C to 251°C
Couleur Blanc
Quantité 25 mg
Merck Index 14,3886
Informations sur la solubilité Insoluble in water.
Rotation optique −107° (c=1 in Methanol/Dichloromethane 1:9)
Poids de la formule 588.56
Forme physique Powder

RUO – Research Use Only

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