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Glimepiride

Code produit 15484489
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Quantité:
100 mg
1 g
Conditionnement:
100mg
1g
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Code produit Quantité Conditionnement
15484489 100 mg 100mg
15474489 1 g 1g
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Code produit 15484489 Fournisseur Thermo Scientific Alfa Aesar Code fournisseur J62032.MC
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Description

A sulfonylurea hypoglecemic agent and potent potassium channel blocker | CAS: 93479-97-1 | C24H34N4O5S | 490.62 g/mol

Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker. Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker. Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.

Solubility
Soluble in DMSO

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Identifiants chimiques

CAS 93479-97-1
Formule moléculaire C24H34N4O5S
Poids moléculaire (g/mol) 490.62
Numéro MDL MFCD00878417
Clé InChI WIGIZIANZCJQQY-UHFFFAOYSA-N
Synonyme glimepiride, amaryl, glimepiridum, glimepirida, amarel, glimepirid, glimepride, endial, roname, glimepiridum latin
CID PubChem 3476
Nom IUPAC 3-ethyl-4-methyl-N-{2-[4-({[(4-methylcyclohexyl)carbamoyl]amino}sulfonyl)phenyl]ethyl}-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
SMILES CCC1=C(C)CN(C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC2CCC(C)CC2)C1=O

Spécification

Nom chimique ou matériau Glimepiride
Point de fusion 212°C to 215°C
Couleur Blanc
Quantité 100 mg
Merck Index 14,4440
Informations sur la solubilité Soluble in DMSO
Poids de la formule 490.62
Forme physique Powder

RUO – Research Use Only

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