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AcroBiosystems GMP Human BMP-4 / BMP2B (improved sequence) Protein

Code produit 31453227
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Code produit Quantité
31453227 1 mg
31452892 50 μg
31452273 10 mg
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Code produit 31453227 Fournisseur AcroBiosystems Code fournisseur GMPBM4H181mg

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Description

Recombinant Protein

GMP Human BMP-4 (improved sequence) Protein (GMP-BM4H18) is expressed from E. coli cells. It is a variant of BMP-4 to suit cell culture applications better.

Bone Morphogenetic Protein 4 (BMP4) is a member of growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. BMP-4 Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. BMP-4 can acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.

Spécification

Numéro d’adhésion NCBI
Caractérisation This protein carries no tag. The protein has a calculated MW of 13.2 kDa. The protein migrates as 13 kDa±3 kDa when calibrated against under reducing (R) condition (SDS-PAGE).
Format Powder-GMP
Formule Lyophilized from 0.22 μm filtered solution in 20 mM Citric acid, pH 2.2 with protectants. Contact us for customized product form or formulation.
Test du contrôle qualité <0.5 ng/μg of protein tested by ELISA.∣<0.02 ng/μg of protein tested by qPCR.∣Less than 50 EU/mg, tested by the LAL method in compliance with USP 85 and Ph. Eur. 2.6.14.∣Sterility testing was performed using the membrane filtration method in compliance with USP &CM and Ph. Eur. 2.6.1.∣Negative
Quantité 1 mg
Source GMP Human BMP-4 (improved sequence) Protein (GMP-BM4H18) is expressed from E. coli cells. It is a variant of BMP-4 to suit cell culture applications better.
Activité biologique GMP Human BMP-4 (improved sequence) Protein (Cat. No. GMP-BM4H18) stimulates Human BMP (Luc) HEK293 Reporter Cell. The specific activity of GMP Human BMP-4 (improved sequence) Protein is >1.90 x 10^3 U/mg (QC tested).∣GMP Human BMP-4 (improved sequence) Protein (Cat. No. GMP-BM4H18) could significantly induce iPSC derived HSPC differentiation, with high expression of CD34 and CD45 (HSPC markers) by flow cytometry analysis and the increase of viable numbers of CD34+ CD45+ cells by cell counting. GMP Human BMP-4 (improved sequence) Protein (Cat. No. GMP-BM4H18) has a similar performance with Human BMP-4 (improved sequence) Protein, premium grade (Cat. No. BM4-H5118).∣The Cell based assay shows that GMP Human BMP-4 (improved sequence) Protein (Cat. No. GMP-BM4H18) is stable at 37°C for 7 hours.∣The Cell based assay shows that GMP Human BMP-4 (improved sequence) Protein (Cat. No. GMP-BM4H18) is stable at 4°C for 180 days.∣The Cell based assay shows that GMP Human BMP-4 (improved sequence) Protein (Cat. No. GMP-BM4H18) is stable after freezing and thawing 3 times.∣The Cell based assay shows batch-to-batch consistency between Acro's GMP and PG BMP-4 (improved sequence).
Espèces Human
Stérilité Sterile
Contenu et stockage -20°C to -70°C for 5 years in lyophilized state; -70°C for 12 months under sterile conditions after reconstitution. Upon receipt, store it immediately at -20°C or lower for long term storage.
Niveau d’endotoxines Less than 50 EU/mg, tested by the LAL method in compliance with USP 85 and Ph. Eur. 2.6.14.
Conditions d’expédition This product is supplied and shipped with blue ice, please inquire the shipping cost.
Pureté ou qualité 0.95
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