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AcroBiosystems GMP Human HGF Protein

Code produit 31452283
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Code produit Quantité
31452283 50 μg
31453791 1 mg
31451997 10 mg
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Code produit 31452283 Fournisseur AcroBiosystems Code fournisseur GMPHGFH2850ug

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Description

Recombinant Protein

HGF, also known as scatter factor and hepatopoietin A, is a pleiotropic protein in the plasminogen subfamily of S1 peptidases , and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include the induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, HGF promotes the motility of cardiac stem cells in damaged myocardium. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear, polypeptide-precursor glycoprotein residues. Proteolytic processing of this precursor generates the biologically active heterodimeric form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held together by a single disulfide bond resulting in formation of a biologically active heterodimer.

HGF, also known as scatter factor and hepatopoietin A, is a pleiotropic protein in the plasminogen subfamily of S1 peptidases , and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include the induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, HGF promotes the motility of cardiac stem cells in damaged myocardium. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear, polypeptide-precursor glycoprotein residues. Proteolytic processing of this precursor generates the biologically active heterodimeric form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held together by a single disulfide bond resulting in formation of a biologically active heterodimer.

Spécification

Numéro d’adhésion Uniprot
Caractérisation HGF Structure This protein carries no tag. The protein has a calculated MW of 79.7 kDa. The protein migrates as 83 kDa±3 kDa when calibrated against under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Format Powder-GMP
Formule Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with protectants. Contact us for customized product form or formulation.
Test du contrôle qualité <0.5 ng/μg of protein tested by ELISA.∣<0.02 ng/μg of protein tested by qPCR.∣Less than 10 EU/mg, tested by the LAL method in compliance with USP 85 and Ph. Eur. 2.6.14.∣Sterility testing was performed using the membrane filtration method in compliance with USP &CM and Ph. Eur. 2.6.1.∣Negative
Quantité 50 μg
Source GMP Human HGF Protein (GMP-HGFH28) is expressed from human 293 cells (HEK293). It contains AA Gln 32 - Ser 728 (Accession # ). Predicted N-terminus: Gln 32 Request for sequence
Activité biologique GMP Human HGF Protein (Cat. No. GMP-HGFH28) stimulates the secretion of IL-11 by Saos-2 cells. The specific activity of GMP Human HGF Protein is >6.00 x 10^5 IU/mg, which is calibrated against WHO Hepatocyte Growth Factor (NIBSC code: 96/556) (QC tested).∣The activity of GMP Human HGF Protein (Cat. No. GMP-HGFH28) was consistent with competing product.∣The Cell based assay shows that GMP Human HGF Protein (Cat. No. GMP-HGFH28) is stable at 37°C for 7 hours.∣The Cell based assay shows that GMP Human HGF Protein (Cat. No. GMP-HGFH28) is stable at 4°C for 180 days.∣The Cell based assay shows that GMP Human HGF Protein (Cat. No. GMP-HGFH28) is stable after freezing and thawing 3 times.∣The Cell based assay shows batch-to-batch consistency between Acro's GMP and PG HGF.
Espèces Human
Stérilité Sterile
Contenu et stockage -20°C to -70°C for 5 years in lyophilized state; -70°C for 12 months under sterile conditions after reconstitution. Upon receipt, store it immediately at -20°C or lower for long term storage.
Niveau d’endotoxines Less than 10 EU/mg, tested by the LAL method in compliance with USP 85 and Ph. Eur. 2.6.14.
Conditions d’expédition This product is supplied and shipped with blue ice, please inquire the shipping cost.
Activité spécifique The activity of GMP Human HGF Protein (Cat. No. GMP-HGFH28) was consistent with competing product.
Pureté ou qualité 0.95
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