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Gibco™ Human FGF-basic (FGF-2/bFGF) (aa 10-155) Recombinant Protein

Product Code. 10202733 Shop All Gibco Products
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Product Code. Quantité Unit Size
10202733 100 μg 100 UG
10612074 1 mg 1 pièce
10622074 10 μg 1 pièce
10222253 50 μg 50 UG
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Product Code. 10202733 Supplier Gibco™ Supplier No. PHG0021
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Description

Recombinant Protein

Carrier-Free Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile, distilled water to 0.1-0.5 mg/mL. Apportion the reconstituted protein into working aliquots and store at ≤-20°C. Make any further dilutions of the reconstituted protein in medium or buffered solution containing carrier protein, such as PBS with 0.1% BSA. Storage: Store the lyophilized protein at 2-8°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at ≤-20°C (not in a frost-free freezer). Avoid repeated freeze-thaw cycles.

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.
TRUSTED_SUSTAINABILITY

Specifications

Numéro d’adhésion P09038
À utiliser avec (application) Bioactivity
Formule Protein with no preservative
Identification génétique (Entrez) 2247
Poids moléculaire 17 kDa
Nom Human FGF-basic (FGF-2/bFGF) (aa 10-155)
Méthode de purification Purified
Quantité 100 μg
Conditions de stockage 4°C
État réglementaire RUO
Concentration en endotoxines <0.1 ng/μg
Alias de gène Basic fibroblast growth factor; basic fibroblast growth factor bFGF; bFGF; FGF; fgf basic; Fgf2; Fgf-2; Fgfb; FGF-b; Fibroblast growth factor; fibroblast growth factor 2; fibroblast growth factor 2 (basic); Fibroblast growth factor basic; HBGF-2; Heparin-binding growth factor 2; H-FGF-b-147; H-FGF-b-154; M-FGF-b; Prostatic growth factor; prostatropin
Nom usuel FGF2
Symbole de gène(s) FGF2
Activité biologique ED50 ≤ 1.0 ng/mL; determined by the dose-dependent proliferation of BALB/3T3 cells.
Type de produit Protein
Conjugué Unconjugated
Espèces Human
Recombinant Recombinant
Séquence Human FGF-basic, amino acids 10-155
Contenu et stockage 4°C
Activité ED50 ≤ 1.0 ng/mL; determined by the dose-dependent proliferation of BALB/3T3 cells.
Niveau d’endotoxines <0.1 ng/μg
Conditions d’expédition Wet Ice
Système d’expression E. coli
Famille de protéines Growth Factors & Receptors
Forme protéique Recombinant, Ligand, Truncated
Forme Lyophilized
Sous-type de protéine FGFs (Fibroblast Growth Factors)
Catégorie de recherche Neurobiology, Oncology, Stem Cell Research, Microbiology, Differentiation, Angiogenesis
Gamme de produits Gibco
Pureté ou qualité >95% by SDS-PAGE
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