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Gibco™ Human IL-10 Recombinant Protein, PeproTech®

Code produit 17890563
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100µg
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500µg
50µg
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Code produit Quantité Conditionnement
17890563 10 μg 10µg
17830513 100 μg 100µg
17821303 1 mg 1mg
17880333 250 μg 250µg
17861073 2 μg 2µg
17800523 500 μg 500µg
17891073 50 μg 50µg
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Code produit 17890563 Fournisseur Gibco™ Code fournisseur 2001010UG
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Description

Recombinant Protein

Recombinant Human IL-10 is an 18.6 kDa protein of 161 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
TRUSTED_SUSTAINABILITY

Spécification

Numéro d’adhésion P22301
À utiliser avec (application) Bioactivity, Control, ELISA Standard, Western Blot Control
Formule Protein with no preservative
Identification génétique (Entrez) 3586
Poids moléculaire 18.6 kDa
Nom Human IL-10
Méthode de purification Purified
Quantité 10 μg
Source E. coli
Conditions de stockage -20°C
État réglementaire RUO
Concentration en endotoxines <1 EU/μg
Alias de gène CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
Nom usuel IL-10
Symbole de gène(s) IL10
Activité biologique Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The ED50 was found to be ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg
Type de produit Protein
Conjugué Unconjugated
Recombinant Recombinant
Séquence MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N
Contenu et stockage -20°C
Activité Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The ED50 was found to be ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg.
Système d’expression E. coli
Forme Lyophilized
Pureté ou qualité ≥ 98% by SDS-PAGE gel and HPLC analyses.
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