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Gibco™ Human Klotho Recombinant Protein, PeproTech®
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Quantité:
100 μg
2 x 500 μg
20 μg
250 μg
5 μg
500 μg
Conditionnement:
100µg
1mg
2 pièces
20µg
250µg
500µg
5µg
Description
100-53-1MG will be provided as 2 x 500 μg (100-53-500UG). Recombinant Human Klotho is a glycoprotein of 516 amino acid residues that migrates at an apparent molecular weight of 65-70 kDa by SDS-PAGE analysis under reducing conditions. Recombinant Human Klotho has a calculated molecular weight of 58.6 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
Spécification
Spécification
| Numéro d’adhésion | Q9UEF7 |
| À utiliser avec (application) | Control, Western Blot Control, Bioactivity |
| Formule | Protein with no preservative |
| Identification génétique (Entrez) | 9365 |
| Poids moléculaire | 58.6 kDa |
| Nom | Human Klotho |
| Méthode de purification | Purified |
| Quantité | 100 μg |
| Source | CHO cells |
| Conditions de stockage | -20°C |
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