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Gibco™ Human Noggin Recombinant Protein, PeproTech®

Código de producto. 17840123
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Quantité:
100 μg
2 x 500 μg
20 μg
250 μg
5 μg
50 μg
500 μg
Tamaño de la unidad:
100µg
1mg
2 pièces
20µg
250µg
500µg
50µg
5µg
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Código de producto. Quantité unitSize
17840123 100 μg 100µg
17880143 2 x 500 μg 1mg
30087766 2 x 500 μg 2 pièces
17811063 20 μg 20µg
17830873 250 μg 250µg
17850883 500 μg 500µg
17850123 50 μg 50µg
17861183 5 μg 5µg
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Código de producto. 17840123 Proveedor Gibco™ N.º de proveedor 12010C100UG

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Description

Recombinant Protein

120-10C-1MG will be provided as 2 x 500 μg (120-10C-500UG). Recombinant Human Noggin is a 46 kDa disulfide-linked homodimer consisting of two 205 amino acid polypeptide chains. Monomeric glycosylated noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
TRUSTED_SUSTAINABILITY

Specifications

Numéro d’adhésion Q13253
À utiliser avec (application) Control, Bioactivity
Formule Protein with no preservative
Identification génétique (Entrez) 9241
Poids moléculaire 46 kDa
Nom Human Noggin
Méthode de purification Purified
Quantité 100 μg
Source HEK293 cells
Conditions de stockage -20°C
État réglementaire RUO
Concentration en endotoxines <1 EU/μg
Alias de gène NOG; Noggin; Noggin precursor; noggin; LOW QUALITY PROTEIN: noggin; SYM1; symphalangism 1 (proximal); SYNS1; SYNS1A
Nom usuel Noggin
Symbole de gène(s) NOG
Activité biologique Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 2.0-3.0 ng/ml of Noggin.
Type de produit Protein
Conjugué Unconjugated
Recombinant Recombinant
Séquence QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCSC
Contenu et stockage -20°C
Activité Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 2.0-3.0 ng/ml of Noggin.
Système d’expression HEK293 cells
Forme Lyophilized
Pureté ou qualité ≥ 95% by SDS-PAGE gel and HPLC analyses.
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