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Gibco™ Human TPO (Thrombopoietin) Recombinant Protein, PeproTech®

Code produit 17859962
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Code produit Quantité Conditionnement
17859962 100 μg 100µg
17811113 10 μg 10µg
17830433 1 mg 1mg
17881713 250 μg 250µg
17850343 2 μg 2µg
17871713 500 μg 500µg
17811813 50 μg 50µg
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Code produit 17859962 Fournisseur Gibco™ Code fournisseur 30018100UG
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Description

Recombinant Protein

Recombinant Human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.
TRUSTED_SUSTAINABILITY

Spécification

Numéro d’adhésion P40225
À utiliser avec (application) Control, Western Blot Control, ELISA Standard, Bioactivity
Formule Protein with no preservative
Identification génétique (Entrez) 7066
Poids moléculaire 18.6 kDa
Nom Human TPO (Thrombopoietin)
Méthode de purification Purified
Quantité 100 μg
Source E. coli
Conditions de stockage -20°C
État réglementaire RUO
Concentration en endotoxines <1 EU/μg
Alias de gène C-mpl ligand; Megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; megakaryocyte stimulating factor; Mgdf; MKCSF; ML; MPL ligand; Mpllg; MSA; Myeloproliferative leukemia virus oncogene ligand; prepro-thrombopoietin; TDH2A; THCYT1; THPO; Thrombopoietin; thyroid microsomal antigen; thyroid peroxidase; thyroperoxidase; Tpo; TPX
Nom usuel Thrombopoietin
Symbole de gène(s) THPO
Activité biologique The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg
Type de produit Protein
Conjugué Unconjugated
Recombinant Recombinant
Séquence SPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNEL
Contenu et stockage -20°C
Activité The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg.
Système d’expression E. coli
Forme Lyophilized
Pureté ou qualité ≥ 98% by SDS-PAGE gel and HPLC analyses.
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