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Invitrogen™ Human IL-6 Recombinant Protein

Code produit 17134213
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Quantité:
5 μg
Conditionnement:
5µg
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Code produit Quantité unitSize
17134213 5 μg 5µg
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Code produit 17134213 Fournisseur Invitrogen™ Code fournisseur A42540

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Description

Recombinant Protein

Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2 mg/mL or lower. It is recommended that the protein be aliquoted and used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.

IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.
TRUSTED_SUSTAINABILITY

Spécification

Numéro d’adhésion P05231
À utiliser avec (application) Control, Binding Assay, Bioactivity, Western Blot
Formule PBS with 5% mannitol, 5% trehalose, 0.01% Tween 80 and no preservative; pH 7.4
Identification génétique (Entrez) 3569
Poids moléculaire 20.95 kDa
Nom Human IL-6
Plage de pH 7.4
Méthode de purification Purified
Quantité 5 μg
Source E. coli
Conditions de stockage -20°C or -80°C if preferred
État réglementaire RUO
Alias de gène B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CHIL-6; CTL differentiation factor; cytokine; HGF; H-IL-6; HSF; hybridoma growth factor; Ifnb2; IFN-beta-2; Il6; IL-6; ILg6; ILN; interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin 6 precursor; interleukin BSF-2; interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 precursor; interleukin-6 protein; M-IL-6; prointerleukin 6; R-IL-6
Nom usuel IL-6
Symbole de gène(s) Il6
Activité biologique 1. Immobilized Human IL-6 Recombinant Protein (at 2 μg/mL (100 μL/well) can bind Human IL-6 R hFc, the EC50 of Human IL-6 R hFc is 3.0-10.0 ng/mL 2. Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.1-0.8 ng/mL 3.Loaded Recombinant Human IL-6 R Protein, His Tag on His1K Biosensor, can bind Human IL-6 Recombinant Protein with an affinity constant of 0.165 μM as determined in BLI assay (Sartorius Octet RED384)(Routinely tested).)
Type de produit Protein
Conjugué Unconjugated
Espèces Human
Recombinant Recombinant
Marqueur de protéine Untagged
Séquence Human IL-6, amino acids Val30-Met212 (Accession # NP_000591.1) with an N-terminal Met
Contenu et stockage Includes 1 vial of lyophilized protein. Store at -20 °C.
Activité 1. Immobilized Human IL-6 Recombinant Protein at 2 μg/mL (100 μL/well) can bind Human IL-6R hFc, the EC50 of Human IL-6R hFc is 3.0-10.0 ng/mL.<br><br>2. Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.1-0.8 ng/mL.<br><br>3.Loaded Recombinant Human IL-6R Protein, His Tag on His1K Biosensor, can bind Human IL-6 Recombinant Protein with an affinity constant of 0.165 μM as determined in BLI assay (Sartorius Octet RED384)(Routinely tested).
Système d’expression E. coli
Famille de protéines Cytokines & Receptors
Forme protéique Full Length, Recombinant
Forme Lyophilized
Sous-type de protéine Interleukins
Catégorie de recherche Immunology, Inflammation, Oncology
Pureté ou qualité >95% by SDS-PAGE
Protéine interleukin 6 (interferon, beta 2)
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