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Gibco™ Mouse LIF Recombinant Protein, PeproTech®

Code produit 17850113
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17850113 1 mg 1mg
17831853 100 μg 100µg
17850513 250 μg 250µg
17841793 25 μg 25µg
17861253 500 μg 500µg
17810223 5 μg 5µg
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Code produit 17850113 Fournisseur Gibco™ Code fournisseur 250021MG

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Description

Recombinant Protein

Recombinant Murine LIF is a 19.9 kDa protein containing 180 amino acids residues, including three disulfide bonds. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.
TRUSTED_SUSTAINABILITY

Spécification

Numéro d’adhésion P09056
À utiliser avec (application) Functional Assay
Formule protein with no preservative
Identification génétique (Entrez) 16878
Poids moléculaire 19.6 kDa
Nom Mouse LIF
Quantité 1 mg
Source E. coli
État réglementaire RUO
Concentration en endotoxines <1 EU/ μg
Alias de gène CDF; cholinergic differentiation factor; cholinergic neuronal differentiation factor; d factor; DIA; differentiation inhibitory activity; differentiation-inducing factor; differentiation-stimulating factor; Emfilermin; hepatocyte-stimulating factor III; HILDA; human interleukin in DA cells; leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor); LIF; Melanoma-derived LPL inhibitor; MLPLI; myeloid leukaemia inhibitory factor
Nom usuel LIF
Symbole de gène(s) Lif
Activité biologique PeproTech's Murine LIF is fully biologically active when compared to standards. The ED50 as determined by the M1 cell differentiation assay is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10^7 units/mg
Conjugué Unconjugated
Recombinant Recombinant
Séquence SPLPITPVNA TCAIRHPCHG NLMNQIKNQL AQLNGSANAL FISYYTAQGE PFPNNVEKLC APNMTDFPSF HGNGTEKTKL VELYRMVAYL SASLTNITRD QKVLNPTAVS LQVKLNATID VMRGLLSNVL CRLCNKYRVG HVDVPPVPDH SDKEAFQRKK LGCQLLGTYK QVISVVVQAF
Contenu et stockage -20°C
Système d’expression E. coli
Forme Lyophilized
Pureté ou qualité ≥ 98% by SDS-PAGE gel and HPLC analyses.
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