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  6. N-acétyl-D-mannosamine, 98 %, Thermo Scientific Chemicals

N-acétyl-D-mannosamine, 98 %, Thermo Scientific Chemicals

Product Code. 10527970 Shop All Thermo Scientific Chemicals Products
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Product Code. 10527970 Supplier Thermo Scientific Acros Supplier No. 427530050
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Description

N-Acetyl-D-mannosamine (ManNAc), CAS # 7772-94-3, is a monosaccharide sialic acid precursor.

Ce produit de la marque Thermo Scientific Chemicals faisait à l’origine partie de la gamme de produits Acros Organics. Certains documents et informations sur l’étiquette peuvent faire référence à la marque héritée. Le code d’article / produit Acros Organics d’origine ou la référence SKU n’a pas changé dans le cadre de la transition de la marque vers Thermo Scientific Chemicals.

General Description

  • N-Acetyl-D-mannosamine (ManNAc) is a precursor used to synthesize N-acetylneuraminic acid, the most common physiologic sialic acid present in humans and other mammals
  • Sialic acids are terminal sugars on glycoconjugates that can modify biochemistry of glycoproteins and lipids, mediate cellular adhesion, and act as immune regulators
  • Defects in sialic acid biosynthesis are associated with a number of pathologies
  • Sialic acids are often found at increased expression levels on tumor cell surfaces

Applications

  • As a sialic acid precursor, N-Acetyl-D-mannosamine can be used in many glycoengineering applications, such as modifying immune cell activity, imaging glycans, or blocking pathogen binding
  • N-Acetyl-D-mannosamine hasbeen used in preclinical laboratory studies as a treatment for hereditary inclusion body myopathy, a progressive neuromuscular disease via increased sialylation of podocalyxin
  • N-Acetyl-D-mannosamine has been used in laboratory studies to induce IgG sialylation and prevent obesity-induced hypertension in mice following high-fat diet
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 7772-94-3
Formule moléculaire C8H17NO7
Poids moléculaire (g/mol) 239.22
Numéro MDL MFCD00149493,MFCD00046758,MFCD00149493,MFCD00069808
Clé InChI VVQPUTSNIMAJPT-UHFFFAOYNA-N
Synonyme n-acetylmannosamine
CID PubChem 11908605
Nom IUPAC N-[(2R,3S,4S,5S,6R)-2,4,5-trihydroxy-6-(hydroxyméthyl)oxan-3-yl]acétamide
SMILES O.CC(=O)NC1C(O)OC(CO)C(O)C1O

Specifications

Nom chimique ou matériau N-Acetyl-D-mannosamine
% min. CAS 97.5
% max. CAS 100.0
Couleur Blanc
Spectre IR Authentic
Plage de pourcentage du dosage 98%
Conditionnement Flacon en verre
Quantité 5 g
Poids de la formule 221.21
Pourcentage de pureté ≥97.5%
Forme physique Poudre cristalline
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