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Gibco™ PeproGMP™ Human BMP-4 Recombinant Protein, PeproTech®

Code produit 30275254
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100 μg
50 μg
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100µg
50µg
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30275254 100 μg 100µg
30275492 50 μg 50µg
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Code produit 30275254 Fournisseur Gibco™ Code fournisseur GMP12005ET100UG

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Description

Recombinant Protein

Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-beta superfamily of structurally related signaling proteins. PeproTech's E. coli-derived Human BMP-4 is a fully active homodimeric protein consisting of two 107 amino acid subunits, which correspond to amino acids 303-408 of the full-length BMP-4 precursor, as well as an N-terminal methionine. PeproTech Recombinant Human BMP-4 is a 24.2 kDa protein. PeproGMP BMP-4 can be used with PeproGMP VEGF-165 and PeproGMP SCF in CTS StemScale medium for pluripotent stem cell differentiation, specifically for mesoderm and hematopoetic progenitor cell induction. Reconstitute using 5mM HCl, pH 3.0 to a concentration of 0.1-1.0 mg/ml. Additional product information, specifications, handling and reconstitution information are provided on the Certificate of Analysis. All PeproGMP™ products are manufactured using animal-derived component free materials. Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products.

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
TRUSTED_SUSTAINABILITY

Spécification

Numéro d’adhésion P12644
À utiliser avec (application) Control, Western Blot Control, Bioactivity
Format Lyophilized
Formule Protein with no preservative
Identification génétique (Entrez) 652
Poids moléculaire 24.2 kDa
Nom PeproGMP™ Human BMP-4
Méthode de purification Purified
Quantité 100 μg
Conditions de stockage -20°C or -80°C if preferred
État réglementaire GMP
Concentration en endotoxines ≤0.1 EU/μg
Alias de gène BMP; BMP2B; BMP-2B; Bmp2b1; Bmp2b-1; Bmp4; Bmp-4; BOMPR4A; Bone morphogenetic protein; Bone morphogenetic protein 2B; bone morphogenetic protein 4; bone morphogenetic protein 4 preproprotein; DVR4; Dvr-4; MCOPS6; OFC11; ZYME
Nom usuel BMP4
Symbole de gène(s) BMP4
Activité biologique Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.
Type de produit Protein
Conjugué Unconjugated
Recombinant Recombinant
Séquence MKKNKNCRRH SLYVDFSDVG WNDWIVAPPG YQAFYCHGDC PFPLADHLNS TNHAIVQTLV NSVNSSIPKA CCVPTELSAI SMLYLDEYDK VVLKNYQEMV VEGCGCR
Contenu et stockage -20°Cor to +80°C if preferred
Activité Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.
Système d’expression E. coli
Forme Lyophilized
Gamme de produits PeproGMP
Pureté ou qualité ≥ 98% by SDS-PAGE gel and HPLC analyses.
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