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Gibco™ PeproGMP® Human IL-2 Recombinant Protein, PeproTech®

Code produit 30276214
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30276214 100 μg 100µg
30275501 1 mg 1mg
30275964 50 μg 50µg
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Code produit 30276214 Fournisseur Gibco™ Code fournisseur GMP20002100UG

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Description

Recombinant Protein

Recombinant Human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond. Additional product information and specifications are provided on the Certificate of Analysis. All PeproGMP® products are manufactured using animal-derived component free materials. Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter 1043 Ancillary Materials for Cell, Gene, and Tissue-Engineered Products. Product use statement: For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.

Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.
TRUSTED_SUSTAINABILITY

Spécification

Numéro d’adhésion P60568
À utiliser avec (application) Control, Western Blot Control, Bioactivity
Format Lyophilized
Formule Protein with no preservative
Identification génétique (Entrez) 3558
Poids moléculaire 15.5 kDa
Nom PeproGMP™ Human IL-2
Méthode de purification Purified
Quantité 100 μg
Conditions de stockage -20°C or -80°C if preferred
État réglementaire GMP
Concentration en endotoxines ≤0.1 EU/μg
Alias de gène aldesleukin; cytokine; H-IL-2; il 2; Il2; Il-2; ILN; Interleukin; interleukin 2; interleukin 2 precursor; interleukin 2 variant IL2delta2; Interleukin2; Interleukin-2; interleukin-2 precursor; interleukin-2 precursor protein; interleukin-2; interleukin 2; Involved in regulation of T cell clonal expansion; involved in regulation of T-cell clonal expansion; lymphokine; M-IL-2; patial sequence of Interleukin-2; POIL2; porcine Interleukin 2; T cell growth factor; T-cell growth factor; T-cell growth factor (TCGF); TCGF
Nom usuel IL-2
Symbole de gène(s) IL2
Activité biologique Determined by the proliferation of mouse CTLL-2 cells. PeproGMP Recombinant Human IL-2 ha been tested against the WHO standard NIBSC 86/500.
Type de produit Protein
Conjugué Unconjugated
Recombinant Recombinant
Séquence MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFAQSII STLT
Contenu et stockage -20°Cor to +80°C if preferred
Activité Determined by the proliferation of mouse CTLL-2 cells. PeproGMP Recombinant Human IL-2 has been tested against the WHO standard NIBSC 86/500. Find the International Unit (IU) value <a href='https://www.thermofisher.com/us/en/home/life-science/cell-culture/cell-culture-learning-center/recombinant-protein-information/international-units.html'>here</a>.
Système d’expression E. coli
Forme Lyophilized
Gamme de produits PeproGMP
Pureté ou qualité ≥ 98% by SDS-PAGE gel and HPLC analyses.
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